NMDA
receptors are formed after the Dorsal Horn is bombarded with pain for an extended
period of time. These are receptors that use a very fast neurotransmitter and
they cause a marked increase in the amount of pain transmitted to the brain.
They also prevent opioids from working to their full effectiveness. Normally,
NMDA receptors are inhibited from firing due to Magnesium ions, but they are
displaced by the constant stimulation of ectopic impulses.
